2025
Hargrave, S. H., Keyser, A. J., Kristal, E., Alexander, G. E., Block, T. A., Bray, E. E., Douglas, L. E. L. C., Kennedy, B. S., Promislow, D. E. L., Raichlen, D. A., Consortium, D. A. P., & MacLean, E. L. (2025). Functional assessments of short-term spatial memory in the Dog Aging Project identify strong associations with age that are not moderated by body mass. GeroScience, 48(1), 1–16. https://doi.org/10.1007/s11357-025-01867-4
McGrath, S., Hull, E., Dunbar, M. D., Prescott, J., Keyser, A. J., MacLean, E., Darvas, M., Latimer, C., Moreno, J., MacCoss, M. J., Kauffman, M., Litwin, P., Castelhano, M., Kaeberlein, M., & Keene, C. D. and. (2025). The companion dog as a translational model for Alzheimer’s disease: Development of a longitudinal research platform and post mortem protocols. Alzheimer’s & Dementia, 21(9). https://doi.org/10.1002/alz.70630
Leighton, S. C., Rodriguez, K. E., Jensen, C. L., MacLean, E. L., Baus, J. J., Ashbeck, E. L., Brown, E. A., Mehl, M. R., Taylor, D. J., van Marle, K., Schwichtenberg, A. J., Bedrick, E. J., & O’Haire, M. E. (2025). Sleep–wake dynamics in veteran–service dog dyads: an exploration of overnight concordance. 48(11). https://doi.org/10.1093/sleep/zsaf177
Leighton, S. C., Hofer, M. E., Miller, C. A., Mehl, M. R., Walker, T. D., MacLean, E. L., & O’Haire, M. E. (2025). Obstacles to inclusion and threats to civil rights: An integrative review of the social experiences of service dog partners in the United States. PLOS ONE, 20(3), e0313864. https://doi.org/10.1371/journal.pone.0313864
Coleman, A. E., Creevy, K. E., Anderson, R., Reed, M. J., Fajt, V. R., Aicher, K. M., Atiee, G., Barnett, B. G., Baumwart, R. D., Boudreau, B., Cunningham, S. M., Dunbar, M. D., Ditzler, B., Ferguson, A. M., Forsyth, K. K., Gambino, A. N., Gordon, S. G., Hammond, H. K., Holland, S. N., … Wilfond, B. S. (2025). Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project. GeroScience, 47(3), 2851–2877. https://doi.org/10.1007/s11357-024-01484-7
2024
Gnanadesikan, G. E., Bray, E. E., Cook, E. N., Levy, K. M., Douglas, L. E., Kennedy, B. S., Tecot, S. R., & MacLean, E. L. (2024). Basal plasma oxytocin & fecal cortisol concentrations are highly heritable and associated with individual differences in behavior & cognition in dog puppies. 165. https://doi.org/10.1016/j.yhbeh.2024.105612
Hargrave, S. H., Bray, E. E., McGrath, S., Alexander, G. E., Block, T. A., Chao, N., Darvas, M., Douglas, L. E. L. C., Galante, J., Kennedy, B. S., Kusick, B., Moreno, J. A., Promislow, D. E. L., Raichlen, D. A., Switzer, L. R., Tees, L., Underwood Aguilar, M., Urfer, S. R., Akey, J. M., … MacLean, E. L. (2024). Characterizing dog cognitive aging using spontaneous problem-solving measures: development of a battery of tests from the Dog Aging Project. GeroScience, 47(1), 23–43. https://doi.org/10.1007/s11357-024-01278-x
Gnanadesikan, G. E., King, K. M., Carranza, E., Flyer, A. C., Ossello, G., Smith, P. G., Steklis, N. G., Steklis, H. D., Carter, C. S., Connelly, J. J., Barnett, M., Gee, N., Tecot, S. R., & MacLean, E. L. (2024). Effects of human-animal interaction on salivary and urinary oxytocin in children and dogs. https://doi.org/10.1016/j.psyneuen.2024.107147
Leighton, S. C., Rodriguez, K. E., Jensen, C. L., MacLean, E. L., Davis, L. W., Ashbeck, E. L., Bedrick, E. J., & O’Haire, M. E. (2024). Service Dogs for Veterans and Military Members With Posttraumatic Stress Disorder: A Nonrandomized Controlled Trial. JAMA Network Open, 7(6), e2414686. https://doi.org/10.1001/jamanetworkopen.2024.14686
Gnanadesikan, G. E., Carranza, E., King, K. M., Flyer, A. C., Ossello, G., Smith, P. G., Steklis, N. G., Steklis, H. D., Connelly, J. J., Barnett, M., Gee, N., Tecot, S., & MacLean, E. L. (2024). Glucocorticoid response to naturalistic interactions between children and dogs. Hormones and Behavior, 161, 105523. https://doi.org/10.1016/j.yhbeh.2024.105523
MacLean, E. L., Carranza, E., Gnanadesikan, G. E., King, K. M., Allen, A. M., Linde-Krieger, L. B., Feldman, R., White-Traut, R. C., Hammock, E. A., Carter, C. S., Leng, G., Tecot, S. R., & Bell, A. F. (2024). Neurophysin I is an analytically robust surrogate biomarker for oxytocin. Psychoneuroendocrinology, 161, 106951. https://doi.org/10.1016/j.psyneuen.2023.106951
2023
Gnanadesikan, G. E., Tandon, D., Bray, E. E., Kennedy, B. S., Tennenbaum, S. R., MacLean, E. L., & vonHoldt, B. M. (2023). Transposons in the Williams–Beuren Syndrome Critical Region are Associated with Social Behavior in Assistance Dogs. Behavior Genetics, 54(2), 196–211. https://doi.org/10.1007/s10519-023-10166-7
Salomons, H., Smith, K. C. M., Callahan-Beckel, M., Callahan, M., Levy, K., Kennedy, B. S., Bray, E. E., Gnanadesikan, G. E., Horschler, D. J., Gruen, M., Tan, J., White, P., vonHoldt, B. M., MacLean, E. L., & Hare, B. (2023). Response to Hansen Wheat et al.: Additional analysis further supports the early emergence of cooperative communication in dogs compared to wolves raised with more human exposure. Learning & Behavior, 51(2), 131–134. https://doi.org/10.3758/s13420-023-00576-2
ManyDogs Project, M. P., Alberghina, D., Bray, E. E., Buchsbaum, D., Byosiere, S.-E., Espinosa, J., Gnanadesikan, G. E., Guran, C.-N. A., Hare, E., Horschler, D. J., Huber, L., Kuhlmeier, V. A., MacLean, E. L., Pelgrim, M. H., Perez, B., Ravid-Schurr, D., Rothkoff, L., Sexton, C. L., Silver, Z. A., & Stevens, J. R. (2023). ManyDogs Project: A Big Team Science Approach to Investigating Canine Behavior and Cognition. Comparative Cognition & Behavior Reviews, 18, 59–77. https://doi.org/10.3819/ccbr.2023.180004
2022
Bray, E. E., Raichlen, D. A., Forsyth, K. K., Promislow, D. E. L., Alexander, G. E., MacLean, E. L., Akey, J. M., Benton, B., Borenstein, E., Castelhano, M. G., Coleman, A. E., Creevy, K. E., Crowder, K., Dunbar, M. D., Fajt, V. R., Fitzpatrick, A. L., Jeffrey, U., Jonlin, E. C., Kaeberlein, M., … Wilfond, B. S. (2022). Associations between physical activity and cognitive dysfunction in older companion dogs: results from the Dog Aging Project. GeroScience, 45(2), 645–661. https://doi.org/10.1007/s11357-022-00655-8
Gnanadesikan, G. E., Hammock, E. A., Tecot, S. R., Lewis, R. J., Hart, R., Carter, C. S., & MacLean, E. L. (2022). What are oxytocin assays measuring? Epitope mapping, metabolites, and comparisons of wildtype & knockout mouse urine. Psychoneuroendocrinology, 143, 105827. https://doi.org/10.1016/j.psyneuen.2022.105827
Jensen, C. L., Rodriguez, K. E., MacLean, E. L., Abdul Wahab, A. H., Sabbaghi, A., & O’Haire, M. E. (2022). Characterizing veteran and PTSD service dog teams: Exploring potential mechanisms of symptom change and canine predictors of efficacy. PLOS ONE, 17(7), e0269186. https://doi.org/10.1371/journal.pone.0269186
Ruple, A., MacLean, E., Snyder-Mackler, N., Creevy, K. E., & Promislow, D. (2022). Dog Models of Aging. Annual Review of Animal Biosciences, 10(1), 419–439. https://doi.org/10.1146/annurev-animal-051021-080937
Herbeck, Y. E., Eliava, M., Grinevich, V., & MacLean, E. L. (2022). Fear, love, and the origins of canid domestication: An oxytocin hypothesis. Comprehensive Psychoneuroendocrinology, 9, 100100. https://doi.org/10.1016/j.cpnec.2021.100100
Horschler, D. J., Bray, E. E., Gnanadesikan, G. E., Byrne, M., Levy, K. M., Kennedy, B. S., & MacLean, E. L. (2022). Dogs re-engage human partners when joint social play is interrupted: a behavioural signature of shared intentionality? Animal Behaviour, 183, 159–168. https://doi.org/10.1016/j.anbehav.2021.11.007
2021
Bryer, M. A. H., Koopman, S. E., Cantlon, J. F., Piantadosi, S. T., MacLean, E. L., Baker, J. M., Beran, M. J., Jones, S. M., Jordan, K. E., Mahamane, S., Nieder, A., Perdue, B. M., Range, F., Stevens, J. R., Tomonaga, M., Ujfalussy, D. J., & Vonk, J. (2021). The evolution of quantitative sensitivity. Philosophical Transactions of the Royal Society B, 377(1844). https://doi.org/10.1098/rstb.2020.0529
Strauss, E. G., McCune, S., MacLean, E., & Fine, A. (2021). Editorial: Our Canine Connection: The History, Benefits and Future of Human-Dog Interactions. Frontiers in Veterinary Science, 8. https://doi.org/10.3389/fvets.2021.784491
Gnanadesikan, G. E., Hammock, E. A., Tecot, S. R., Carter, C. S., & MacLean, E. L. (2021). Specificity of plasma oxytocin immunoassays: A comparison of commercial assays and sample preparation techniques using oxytocin knockout and wildtype mice. Psychoneuroendocrinology, 132, 105368. https://doi.org/10.1016/j.psyneuen.2021.105368
Applebaum, J. W., MacLean, E. L., & McDonald, S. E. (2021). Love, fear, and the human-animal bond: On adversity and multispecies relationships. Comprehensive Psychoneuroendocrinology, 7, 100071. https://doi.org/10.1016/j.cpnec.2021.100071
Salomons, H., Smith, K. C., Callahan-Beckel, M., Callahan, M., Levy, K., Kennedy, B. S., Bray, E. E., Gnanadesikan, G. E., Horschler, D. J., Gruen, M., Tan, J., White, P., vonHoldt, B. M., MacLean, E. L., & Hare, B. (2021). Cooperative Communication with Humans Evolved to Emerge Early in Domestic Dogs. Current Biology, 31(14), 3137–3144.e11. https://doi.org/10.1016/j.cub.2021.06.051